Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators

K Hamasaki; A Ueno

doi:10.1016/s0960-894x(01)00005-1

Aminoglycoside antibiotics, neamine and its derivatives as potent inhibitors for the RNA-protein interactions derived from HIV-1 activators

Bioorg Med Chem Lett. 2001 Feb 26;11(4):591-4. doi: 10.1016/s0960-894x(01)00005-1.

Authors

K Hamasaki¹, A Ueno

Affiliation

¹ Department of Bioengineering, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohamna, Japan. khamasak@bio.titech.ac.jp

PMID: 11229778
DOI: 10.1016/s0960-894x(01)00005-1

Abstract

Neamine derivatives which have an arginine (RN), a pyrene (PCN) and both pyrene and arginine (PRN) have been prepared and their binding toward the RNA fragments derived from HIV-1 activator region, TAR and RRE RNA were examined. Among them, PRN bound either TAR RNA or RRE RNA with equivalent binding affinities as Tat and Rev peptide, respectively.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amino Acid Sequence
Anti-Bacterial Agents / pharmacology*
Binding Sites
Gene Products, rev / metabolism*
Gene Products, tat / metabolism*
HIV-1 / drug effects*
HIV-1 / metabolism
Molecular Sequence Data
Neomycin / pharmacology*
RNA, Viral / metabolism*
rev Gene Products, Human Immunodeficiency Virus
tat Gene Products, Human Immunodeficiency Virus

Substances

Anti-Bacterial Agents
Gene Products, rev
Gene Products, tat
RNA, Viral
rev Gene Products, Human Immunodeficiency Virus
tat Gene Products, Human Immunodeficiency Virus
Neomycin